منابع مشابه
Topically applied minoxidil in baldness.
Minoxidil, an orally administered, peripheral vasodilator used to treat hypertension, causes hypertrichosis in more than 80% of users. The drug reduces elevated blood pressure by decreasing peripheral vascular resistance. Chemically, minoxidil i s 2,4-diamino-6-piperidinopyrimidine-3-oxide; it is soluble in water to the extent of approximately 2 mg/ml, i s more readily soluble in propylene glyc...
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Ceramides (CERs), structural components of the stratum corneum (SC), impart essential barrier properties to this thin outer layer of the epidermis. Variations in CER species within this layer have been linked to several skin diseases. A recent proliferation of CER-containing topical skin-care products warrants the elucidation of CER penetration profiles in both healthy and diseased skin. In the...
متن کاملSystemic absorption of topically applied chloramphenicol eyedrops.
Five children under the age of 9 years had topical chloramphenicol drops administered 2-hourly to each eye for 5 to 7 days. Systemic absorption was not detected by 2 sensitive assays for the drug. The hazards of topical chloramphenicol and reports in the current literature are discussed.
متن کاملSystemic Absorption of Topically Applied Salicylic Acid
Salicylic acid was applied topically to the skin of rabbits and humans in order to study the pharmacokinetics of percutaneous absorption, and the effects of formulation and application variables on the rate and extent of absorption. Drug samples incorporated into hydrophilic ointment (USP} and hydrophilic ointment containing 10% urea, were applied to the shaved abdominal areas of female New Zea...
متن کاملSystemic toxicity from topically applied salicylic acid.
Topically applied salicylic acid has enjoyed long and extensive usage as an agent to enhance desquamation in various hyperkeratotic skin diseases. In some of these disorders much of the skin surface may be affected, resulting in the potential for significant percutaneous absorption of the drug. We describe a patient who gradually developed evidence of severe salicylate toxicity while being trea...
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ژورنال
عنوان ژورنال: International Journal of Dermatology
سال: 2007
ISSN: 0011-9059
DOI: 10.1111/j.1365-4362.1985.tb05727.x